Pharvaris Careers

Pharvaris is a late-stage biopharmaceutical company developing novel, oral bradykinin B2 receptor antagonists to potentially address all types of bradykinin-mediated angioedema. By targeting this clinically proven therapeutic target with novel, oral small molecules, the Pharvaris team is advancing new alternatives to injected therapies for the prevention and treatment of hereditary angioedema (HAE) attacks, and other bradykinin B2-receptor-mediated indications. HAE is a rare and potentially life-threatening genetic disease and people living with HAE can suffer sudden and prolonged attacks of swelling in multiple areas of the body, including the airway, which can be life-threatening.

We are expanding our Technical Operations, Global Supply Chain team and are looking for a Director, U.S. Supply Chain to join our team and report to the Head of Global Supply Chain.

We have a culture built on the core values of considering others carefully, leading with trust, ensuring rigor and diversity of thought, and contributing freely.

Our company is driven by individuals committed to developing breakthrough therapies which can have a real impact on people’s lives. If you are looking for a place where your work can have meaning, and you can make a difference – Pharvaris is the place for you.

Location

We have offices in Switzerland (Zug), the Netherlands (Leiden) and the U.S. (greater Boston area) and, at Pharvaris, we promote and enable a flexible hybrid work-environment and support our talent to be home based and work virtually. Whilst this is a remote/hybrid role, you must be located in the U.S. (Greater Boston area strongly preferred).

Responsibilities for this role include:

Core responsibilities

• Set up and lead the U.S. Supply Chain operations, including purchasing and logistics in agreement with the Global Supply Chain Head and the other Pharvaris functions. Focus on efficiency, costs optimization and strategic partnership
• Support the selection of the Third Party Logistic (3PL) provider in U.S., lead the negotiation and its implementation. Manage the selected 3PL and coordinate the related warehouse operations along with all related product movements (receipts, stocktaking, waste, shipments, sampling, etc). Lead Quarterly Business review Meetings with the 3PL
• Coordinate the implementation of the Order to Cash process with the 3PL in collaboration with Finance and Market Access
• Ensure GMP, Customs and Trade compliance in the U.S. Supply Chain operations are compliant with relevant regulations and industry standards
• Monitor U.S. Inventories. Participate into the Global S&OP process. Align with Commercial on Sales Forecast and Supply Plan to meet demand. Coordinate handling of Sales Forecast in the ERP system
• Monitor Forecast Accuracy and propose improvements. Provide regular reporting to senior leadership on key performance indicators (KPIs) such as forecast accuracy, supply performance, and inventory turnover
• Design and implement supply chain processes to enable U.S. product launch and ensure seamless post launch Supply Chain operations
• Take responsibility for supply risk management for the U.S. territory (stock levels of finished product, storage locations, disruptions, etc)
• Support implementation of the ERP system for the U.S. supply chain operations: definition of business processes (import, logistics, repackaging, inventory management, order to cash), testing, training. Manage the U.S. supply chain operations in the ERP system

Other responsibilities include:

• Coordinate implementation of the Serialization system for U.S. operations. Develop processes to maintain compliance, communicate and manage exceptions with external stakeholders
• Coordinate repackaging operations with external Packaging CMO in U.S.
• Coordinate development of U.S. packaging labelling artwork in collaboration with Regulatory Affairs, Commercial, external agencies and Packaging CMOs
• Support Early Access Program in U.S. as required
• Provide ad hoc support for other Supply Chain initiatives (i.e. packaging tech transfer, logistics, distribution, validation, launch excellence, GxP compliance, etc)
• Identify areas for improvement within the supply chain, implementing best practices, and driving continuous optimization efforts

Requirements/Key Attributes:

• Bachelor’s degree in business, Supply Chain, Operations or related field; advanced degree preferred
• At least 7+ years of experience in Supply Chain or related roles within the pharmaceutical or medical devices in U.S.
• Proven track record in leading logistics and planning processes in a complex, regulated environment; strong understanding of pharmaceutical supply chains, including manufacturing, distribution, and regulatory consideration; experience in launching new products in several geographies
• High proficiency in English, written and spoken. Additional European languages are a plus

We are looking for someone with:

• Strong leadership and experience in leading cross-functional teams in a matrix environment
• Excellent communication skills in a multi-cultural environment in an international company, both written and verbal, with the ability to engage and influence senior stakeholders and external Service Providers
• Advanced analytical skills, including proficiency in supply plans, inventory optimization and financial analysis
• Ability to navigate ambiguity in a fast-growing company and drive consensus across diverse teams
• Comfortable in a small company environment that is fast paced, challenging and where all senior staff must take on a hands-on approach to get results
• Deep understanding of ERP systems (e.g. Microsoft Dynamics, SAP, Oracle) and their application in a global context. Daily use of analytical IT tools
• Strong project management skills, with the ability to handle multiple priorities and lead complex initiatives
• Knowledge of global pharmaceutical regulations (e.g. GxP, CSV) and market access dynamics is a significant advantage
• Strategic thinker with a strong focus on execution
• Results-driven and customer-focused, with the ability to balance short-term and long-term objectives. Proven ability to drive continuous improvement and achieve results

Interested?

Please send your resume to careers@pharvaris.com. We look forward to speaking to you.

Pharvaris is a late-stage biopharmaceutical company developing novel, oral bradykinin B2 receptor antagonists to potentially address all types of bradykinin-mediated angioedema. By targeting this clinically proven therapeutic target with novel, oral small molecules, the Pharvaris team is advancing new alternatives to injected therapies for the prevention and treatment of hereditary angioedema (HAE) attacks, and other bradykinin B2-receptor-mediated indications. HAE is a rare and potentially life-threatening genetic disease and people living with HAE can suffer sudden and prolonged attacks of swelling in multiple areas of the body, including the airway, which can be life-threatening.

We are expanding our global Medical Affairs team and are looking for a North America Medical Affairs Lead to join our team and report to the Vice President, Global Head of Medical Affairs.

We have a culture built on the core values of considering others carefully, leading with trust, ensuring rigor and diversity of thought, and contributing freely.

Our company is driven by individuals committed to developing breakthrough therapies which can have a real impact on people’s lives. If you are looking for a place where your work can have meaning, and you can make a difference – Pharvaris is the place for you!

Location

We have offices in Switzerland (Zug), the Netherlands (Leiden) and the U.S. (greater Boston area) and, at Pharvaris, we promote and enable a flexible hybrid work-environment and support our talent to be home based and work virtually. Whilst this is a remote/hybrid role, you must be located in the U.S. (Greater Boston area strongly preferred).

Responsibilities for this role include:

• Serve as the primary expert and contact, for external and internal stakeholders, for in-depth medical/scientific matter related to bradykinin-mediated angioedema in North America
• Leverage and analyze medical information obtained from HCPs, patients, payers, and other stakeholders and translate into actionable insights informing strategic and operational decisions and execution of medical projects
• Develop and implement medical education programs and educational materials for HCPs and patients and provide Medical Affairs support to development of promotional programs (e.g., speaker program)
• Present scientific and medical data at North American Medical Affairs events, such as advisory boards, Investigators’ meetings and during scientific exchanges with external stakeholders, including HCPs, Investigators, payers
• Collaborate with the Head of North America Medical Affairs and contribute to the execution of the Medical Affairs strategy for bradykinin-mediated angioedema in the region, aligned with global strategies and the company’s mission and objectives. Including ensuring the field team (Medical Affairs/ Commercial) receives needed HAE training and support
• Build and nurture relationships with external stakeholders (including HCPs, healthcare institutions, payers, and advocacy groups) in the bradykinin-mediated angioedema landscape
• Partner with Evidence and Outcomes Research and Clinical Development to develop the data generation strategy for North America to address identified medical/scientific data gaps, in close collaboration and alignment with North American Medical Experts

Requirements/Key Attributes:

• Advanced scientific degree in life sciences (MD, PhD, PharmD – MD is a plus)
• At least 8-10 years in U.S. Medical Affairs in Pharma/Biotech industry, including roles such as Medical Lead/Advisor for rare conditions at the time of pre-launch preparation and launch execution (experience in Allergy/Immunology and/or specifically in Hereditary Angioedema is preferred)
• Strong experience in acting as subject matter expert of medical-related content to address inquires of external and internal stakeholders
• Proven ability to interact efficiently with both scientific/medical as well as commercial functions to translate data and evidence into medical and cross-functional strategically-aligned, accurate, balanced, and stakeholder-relevant information
• Demonstrated ability to establish trusted relationships and partnerships with Key Medical Experts, clinicians, and researchers through scientific engagement and translate medical insights into actionable information addressing stakeholders’ unmet needs
• Experience in Outcome Research and in interactions and partnership with Managed Care Professionals is preferred
• Readiness to travel to the degree appropriate to support the business, primarily within North America. Average travel time estimated up to 30% on a monthly basis at the time of specific events (e.g., scientific conferences, business meetings)

We are looking for someone that embodies:

• Proactive thinking and leadership of Medical and cross-functional decisions
• Strategic thinking, combining scientific rigor, business acumen, and entrepreneurial mindset
• Excellent communication and presentation skills to deliver strategic-aligned, effective presentation of complex projects to internal and external partners
• Ability to motivate, influence, negotiate, and collaborate with internal and external stakeholders through efficient management of relationship within a cross-functional matrix
• Strong planning and project management skills, ability to cope under pressure with conflicting priorities, handling ambiguity and changes in a rapidly-evolving environment while maintaining an action- and result-oriented “can-do” approach
• High level of integrity and adherence to applicable Healthcare Compliance and Regulatory standards, guidelines, and policies as applicable to Medical Affairs and to cross-functional teams

Interested?

Please send your resume to careers@pharvaris.com. We look forward to speaking to you.