Pharvaris Careers

Pharvaris is a late-stage biopharmaceutical company developing novel, oral bradykinin B2 receptor antagonists to potentially address all types of bradykinin-mediated angioedema. By targeting this clinically proven therapeutic target with novel, oral small molecules, the Pharvaris team is advancing new alternatives to injected therapies for the prevention and treatment of hereditary angioedema (HAE) attacks, and other bradykinin B2-receptor-mediated indications. HAE is a rare and potentially life-threatening genetic disease and people living with HAE can suffer sudden and prolonged attacks of swelling in multiple areas of the body, including the airway, which can be life-threatening.

We are expanding our U.S. Commercial team and are looking for a U.S. Commercial Data, Systems & Digital Experience Lead, to join our team and report to our Head of Commercial Operations.

We have a culture built on the core values of considering others carefully, leading with trust, ensuring rigor and diversity of thought, and contributing freely.

Our company is driven by individuals committed to developing breakthrough therapies which can have a real impact on people’s lives. If you are looking for a place where your work can have meaning, and you can make a difference – Pharvaris is the place for you!

Location

At Pharvaris we promote and enable a flexible hybrid work environment, where our employees choose from where (and to some extent when) they prefer to work. Whilst this is a remote/hybrid role, you need to be in the U.S.

Responsibilities

• Lead and implement the launch planning by initiating, developing and communicating (internal/external) a process, system, and data roadmap in support of future product launch and commercialization. Including maintaining and updating the roadmap over time
• Support strategic positioning by shaping and driving growth, innovation and differentiation across the U.S. commercial organization, while maintaining alignment with other functions both in the U.S. and Europe.
• Oversee how data is consistently connected and captured across functions within the company in a timely consistent manner to deliver value to HCPs, patients, payors, and employees
• Implement and develop capability development and strategy to drive business value across key commercial capabilities including, but not limited to, operations, market access, product launch, patient services, digital engagement, HCP services, marketing, sales and analytics. Acting as a trusted advisor to these areas of the company, with the ability to work with stakeholders at all levels to guide and co-create new capabilities to support the establishment of the commercial business
• Lead and support IT integration, this role will collaborate strongly with our IT operations and architecture team to deliver a digital and user-friendly experience in support of the commercial team
• Execute and support on the day-to-day commercial data and application operations while also delivering projects and enhancements to current systems. This may include coordinating several external vendors and performing vendor management activities
• Build digital capabilities in scope of this role, but not limited to; data warehousing, data acquisition and integration (internal/external), Master Data Management (HCP, Patient Products, Payor/Plan), Field force automation (sales, MSL etc.), Data change request processes, Campaign automation, Data visualization and analytics (dashboards), Learning management, Consent management and data privacy, Non-personal promotion

Requirements

• Bachelor’s degree; MBA or advanced degree a plus
• A minimum of 10 years’ experience working in the pharmaceutical or biotech industry
• 3 – 5 years’ experience of successfully leading an IT/applications function
• 3 – 5 years’ experience with implementation and building a CRM/SFA
• Proven track record of building operational processes from scratch in a fast-paced, startup or small-company environment
• Demonstrated ability to influence laterally and vertically; ability to influence without authority, motivate teams, and maintain high levels of respect for and from peers
• Experience with specialty pharmacy distribution and patient-level data
• Strong project management skills with the ability to handle multiple priorities and cross-functional stakeholders
• Excellent communication skills, able to translate complex information into clear, actionable recommendations

We are looking for someone that has/is:

• Patient-first mindset that puts patients at the center while balancing purpose and performance
• Big picture thinking through connecting the cross-functional dots, anticipates what is next and drives strategy
• Strong influencing skills and can build trust-based partnerships and thrive in a fast-paced environment
• Drive for results, by being ambitious, resilient and committed in pursuing excellence where it matters most
• Strong problem-solving skills: can turn complex matters into clarity, can easily and quickly adept and is driven by continuous learning
• Integrity is one of their core values; someone that champions transparency, accountability and ethical decision making

Pharvaris is a late-stage biopharmaceutical company developing novel, oral bradykinin B2 receptor antagonists to potentially address all types of bradykinin-mediated angioedema. By targeting this clinically proven therapeutic target with novel, oral small molecules, the Pharvaris team is advancing new alternatives to injected therapies for the prevention and treatment of hereditary angioedema (HAE) attacks, and other bradykinin B2-receptor-mediated indications. HAE is a rare and potentially life-threatening genetic disease and people living with HAE can suffer sudden and prolonged attacks of swelling in multiple areas of the body, including the airway, which can be life-threatening.

We are expanding our U.S. Commercial team and are looking for a Commercial Effectiveness & Training Lead, to join our team and report to our VP, Head of Sales & Marketing.

We have a culture built on the core values of considering others carefully, leading with trust, ensuring rigor and diversity of thought, and contributing freely.

Our company is driven by individuals committed to developing breakthrough therapies which can have a real impact on people’s lives. If you are looking for a place where your work can have meaning, and you can make a difference – Pharvaris is the place for you!

Location

At Pharvaris we promote and enable a flexible hybrid work environment, where our employees choose from where (and to some extent when) they prefer to work. Whilst this is a remote/hybrid role, you need to be in U.S.

Responsibilities

• Partner with commercial leadership to define and implement key commercial priorities and performance strategies across the U.S. field team
• Lead the development, delivery, and evolution of all field-facing training initiatives, including onboarding, advanced selling skills, brand-specific training, and pull-through tactics
• Design and deliver impactful learning experiences based on adult learning principles, collaborating with internal teams and external vendors
• Serve as a critical liaison between the field and cross-functional partners (e.g., Marketing, Market Access, Patient Services, Analytics) to ensure alignment of messaging, priorities, and execution
• Support field force effectiveness through the selection, deployment, and optimization of tools, systems, and performance measurement platforms in close collaboration with Commercial Operations
• Assess field capabilities and proactively identify skill and/or knowledge gaps, including building plans to close those gaps through targeted development
• Shape and lead national field meetings and learning events, ensuring content, logistics, and tone align with business goals and culture
• Partner with Commercial Operations and Incentive Compensation to ensure goals, KPIs, and compensation design support desired performance outcomes
• Contribute to field force readiness for future launches, helping to scale capabilities and operational effectiveness in a growing organization
• Create and maintain continuous improvement mindset—evaluate training impact, field feedback, and performance trends to refine programs

Requirements

• Bachelor’s degree required; advanced degree preferred
• Minimum 8 years of experience in the pharmaceutical or biotech industry, with significant time spent in both field roles and sales leadership
• Proven success in leading commercial or cross-functional initiatives tied to training, enablement, or commercial execution
• Deep understanding of adult learning principles and experience in building effective learning programs
• Excellent collaboration and communication skills—able to build trust, influence without authority, and drive progress across matrixed teams
• Strategic mindset with strong operational skills; comfortable balancing long-term planning with day-to-day execution
• Experience with vendor management and training delivery platforms
• Familiarity with rare disease markets, especially patient-centric and access-sensitive environments, preferred
• Ability to travel 30–40% for internal meetings and field engagements

We are looking for someone that has/is:

• Patient-first mindset with a sense of urgency to deliver results
• Big-picture thinker who connects cross-functional dots to shape smart, future-focused strategies. Operates with an owner’s mindset, balancing risk, opportunity, and resources to drive growth in a fast-evolving landscape
• Trusted partner that builds strong, trust-based relationships across functions. Leads through influence, not title. Navigates ambiguity and conflict with emotional intelligence, driving alignment and shared success in a startup-paced environment
• Competitive drive for results fueled by ambitious goals and personal excellence Demonstrates tenacity, resilience, and a relentless pursuit of success. Holds self to high performance standards and thrives in environments where results matter
• Problem-solving mindset with strong critical thinking and data literacy. Translates complexity into clarity. Solves problems creatively and pragmatically, with a bias for action and continuous learning
• Commitment to integrity in every decision. Champions a culture of accountability, transparency, and ethical decision-making. Proactively embeds compliance into an operational mindset

Pharvaris is a late-stage biopharmaceutical company developing novel, oral bradykinin B2 receptor antagonists to potentially address all types of bradykinin-mediated angioedema. By targeting this clinically proven therapeutic target with novel, oral small molecules, the Pharvaris team is advancing new alternatives to injected therapies for the prevention and treatment of hereditary angioedema (HAE) attacks, and other bradykinin B2-receptor-mediated indications. HAE is a rare and potentially life-threatening genetic disease and people living with HAE can suffer sudden and prolonged attacks of swelling in multiple areas of the body, including the airway, which can be life-threatening.

We are expanding our U.S. Commercial team and are looking for a U.S. Portfolio Marketing Lead, to join our team and report to our VP, Head of Sales & Marketing.

We have a culture built on the core values of considering others carefully, leading with trust, ensuring rigor and diversity of thought, and contributing freely.

Our company is driven by individuals committed to developing breakthrough therapies which can have a real impact on people’s lives. If you are looking for a place where your work can have meaning, and you can make a difference – Pharvaris is the place for you!

Location

At Pharvaris we promote and enable a flexible hybrid work environment, where our employees choose from where (and to some extent when) they prefer to work. Whilst this is a remote/hybrid role, you need to be in U.S. and preferably in Greater Boston Area.

Responsibilities

• Portfolio Strategy Leadership: Build and lead the portfolio marketing function across Pharvaris’ late-stage and future pipeline assets, aligning strategic priorities across HCP, patient, and payer marketing
• Customer-Centric Planning: Develop and execute the customer strategy across the treatment journey, defining audience segments, insights, and activation plans that support brand objectives
• Team Leadership: Build and lead a growing portfolio marketing team from scratch, fostering a culture of performance, curiosity, and collaboration
• Strategic Commercial Contribution: Partner with the Commercial Leadership Team to shape short- and long-term strategies that drive launch excellence and market leadership
• Cross-Functional Leadership: Represent the voice of the customer across all commercial and clinical development stages. Work in close partnership with Sales, Medical, Market Access, Regulatory, Legal, and Compliance to ensure aligned and compliant execution
• Insight Generation: Lead market research and insight development efforts that inform positioning, messaging, branding, and customer activation strategies
• Launch Planning & Execution: Drive brand readiness and customer engagement strategies for Pharvaris’ first product launch and help establish frameworks for future assets
• Brand Evolution: Shape the evolution of Pharvaris’ brand identity, values, and visual expression in a way that inspires internal and external stakeholders
• Agency & Vendor Management: Oversee and optimize the performance of external agency partners and marketing vendors
• Budget Management: Manage the annual portfolio marketing budget and optimize resource allocation across programs and priorities

Requirements

• Bachelor’s degree required; advanced degree (MBA, MPH, etc.) preferred
• Minimum of 10 years of commercial experience in biotech/pharma/agency, including at least 5 years in marketing leadership roles
• Proven track record in launch planning and execution—ideally in rare disease, immunology, or specialty categories
• At least 3 years of experience building and leading high-performance marketing teams
• Deep experience applying insight generation and customer segmentation to drive successful brand strategies
• Experience leading matrixed initiatives across functions such as Medical, Market Access, Legal, and Sales
• Strong strategic, analytical, and problem-solving skills with the ability to translate complex data into actionable insights
• Exceptional written and verbal communication skills; ability to influence across all levels of the organization

Comfortable working in a fast-paced, evolving environment with an entrepreneurial mindset.

We are looking for someone that has/is:

• Patient-first mindset with a sense of urgency to deliver results
• Big picture thinker that connects cross-functional dots to shape smart, future-focused strategies. Operates with an owner’s mindset balancing risk, opportunity, and resources to drive growth in a fast-evolving landscape
• Trusted partner that builds strong, trust-based partnerships across functions. Leads through influence, not title. Navigates ambiguity and conflict with emotional intelligence, driving alignment and shared success in a startup paced environment
• Competitive drive for results that is motivated by ambitious goals and personal excellence. Demonstrates tenacity, resilience, and a relentless pursuit of success. Holds self to high performance standards and thrives in environments where results matter
• Problem-solving mindset that can think critically and leverage data intelligently. Translates complexity into clarity. Solves problems creatively and pragmatically, with a bias for action and continuous learning
• Drive to lead with integrity in every decision. Champions a culture of accountability, transparency, and ethical decision making. Proactively embeds compliance into an operational mindset

Pharvaris is a Nasdaq listed late-stage biotech company developing bradykinin B2 receptor antagonists for bradykinin-mediated diseases, with offices in Switzerland (Zug), the Netherlands (Leiden) and the USA (greater Boston area). We aim at bringing new, more convenient options to HAE patients who suffer sudden and prolonged attacks of swelling in multiple areas of the body including the airway, which can be life-threatening. We have a culture built on the core values of considering others carefully, leading with trust, ensuring rigor and diversity of thought, and contributing freely. Our company is driven by individuals committed to developing breakthrough therapies which can have a real impact on people’s lives. If you are looking for a place where your work can have meaning and you can make a difference – Pharvaris is the place for you!

We are now looking to add capabilities to our regulatory team, considering ongoing and upcoming filings in Europe and the United States, and seeking to therefore hire a Regulatory Affairs CMC writer, to join our Regulatory Affairs team and report to our Senior Director, Regulatory Affairs CMC.

This role will work collaboratively with the Regulatory, R&D and Technical Operations teams on writing projects for early and late-stage development programs. The selected candidate will be tasked with drafting, reviewing and finalizing CMC content and modules for INDs and CTAs, and later, should our clinical trials be successful will also help prepare NDA and MAA related content for the FDA, EMA and other regulatory bodies as needed.

Location

This role is preferably based in Switzerland. At Pharvaris, we promote and enable a flexible hybrid work-environment and support our talents to be home based and work virtually.

Responsibilities

• Author CMC sections for filing and maintenance of INDs, CTAs, IMPDs, NDAs and MAA submissions as well as CMC source documentation for our clinical programs
• Collaborate with Regulatory colleagues to execute CMC submissions and authoring strategy for assigned projects
• Proactively plan and manage writing activities across assigned projects as needed, ensuring adherence to the technical writing strategy and alignment with regulatory & health authorities’ requirements
• Ensure consistency across all communications including all technical documents
• Act as the technical writing expert for CMC regulatory submission documents in cross-functional project teams
• Adhere to generally accepted writing standards to support CMC documentation
• Create and maintain core documentation dossiers utilizing internal templates and tools
• Participate in cross-functional team projects as needed
• Proactively identify process improvement opportunities which align with business needs, and propose and deploy solutions as needed

Requirements

• Bachelor’s degree in Life Sciences required; advanced degree such as MSc, PharmD or PhD is a plus.
• 5+ years of experience in Regulatory CMC in a pharmaceutical or biotechnology setting
• Possess a strong understanding of quality and technical requirements for the preparation of source documents and regulatory dossier content, with the ability to critically assess such documentation, identify gaps or inconsistencies, and work proactively with technical and quality teams to ensure completeness and regulatory readiness.
• Prior experience with FDA related submissions is required, prior experience with EMA, Japan and China submissions is a plus
• Regulatory CMC writing experience for small molecules and/or rare diseases is a plus
• Demonstrated expertise in developing CMC content in briefing documents, quality amendments, module 2 and 3 updates as well as CMC source documents in support of US and global regulatory submissions
• Excellent IT skills including MS Excel, as well as authoring technologies and document management systems
• Experience with eCTD is a plus, understanding of general electronic submissions guidelines is a must
• Experience with StartingPoint templates is a plus
• Highly effective communication and collaboration skills (verbal and written in English), excellent analytical skills and attention to detail
• Ability to manage several priorities & work independently while optimally delivering results
• Comfortable in a small company environment that is fast paced, challenging and where all leaders must take on a hands-on approach to get results

Pharvaris, a public and clinical stage company developing bradykinin B2 receptor antagonists for bradykinin-mediated diseases, has an opportunity for a highly motivated Clinical Development Lead, to join and help drive clinical development and compliance efforts.

The Clinical Development Lead will provide medical input to clinical development and Global Program Teams (GPTs), serve as medical expert for the study teams and medical monitor for phase 1-3 clinical trials. This position offers substantial opportunities for scientific interactions and career advancement in the fast-moving area of rare diseases. Reports to Head of Clinical Development, who is based in the United States (East Coast)

Location

This role is preferably based in the Unites States (MA). Pharvaris supports its staff to be home based and work virtually.

Main Activities

• Developing and setting long and short-term objectives according to defined global clinical strategies and discussing them with clinical staff.
• Strategic guidance to phase 1-3 development programs and oversight of global clinical trials/trial teams on assigned programs.
• Capable to lead study protocol development, oversee study execution and final study report development
• Capable to address safety issues reported in responsible program and development mitigation plan
• Participation in Clinical Team and Operations meetings, explaining and discussing the necessary program expenses and budgets. Medical Expert for clinical study teams.
• Assessing new medical information and data on therapeutic areas and designing related clinical strategies to steer the development of products.
• Presentation at academic congresses, investigator meetings and advisory meetings.
• In preparation for submission, scientifically writing and reviewing clinical parts of submission dossiers from a medical perspective to ensure agreement with global strategies.
• Due diligence: assessing and evaluating clinical strategies and/ or policies of external parties.
• Participating in external professional bodies to identify potential spokesperson and create key opinion leaders for the relatively unknown areas of assigned therapeutic areas.
• Keeping up to date with scientific development within the therapeutic areas and providing appropriate training to staff.

Essential Requirements, Experience and Competencies

• MD, preferably with a relevant specialization (eg:,immunology, gastroenterology, hematology nephrology).
• 5+ years of industry experience of clinical development, especially in rare diseases.
• Regulatory experience, especially with successful IND, NDA submission experience preferred.
• Excellent written / oral communication skills. English is company language.
• Attention to detail and ability to think strategically.
• Willingness to take on new responsibilities.
• Interest and ability to learn about new therapeutic areas.
• Able to manage multiple projects and collaborate across various functional groups.
• Ability to thrive in a dynamic environment with high level of agility; a wide degree of creativity and strategic thinking is expected.
• Comfortable in a small company environment that is fast paced, challenging and where all leaders must take on a hands-on approach to get results.
• Willingness to travel to conferences, scientific advisory meetings, trial sites, investigator meetings: approximately 25%.